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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRP6
All Species:
28.48
Human Site:
Y1522
Identified Species:
56.97
UniProt:
O75581
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75581
NP_002327.2
1613
180443
Y1522
Y
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
Chimpanzee
Pan troglodytes
XP_001152103
1613
180424
Y1522
Y
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
Rhesus Macaque
Macaca mulatta
XP_001117791
1209
134638
K1119
L
H
G
L
R
N
V
K
A
I
D
Y
D
P
L
Dog
Lupus familis
XP_534886
1613
180464
Y1522
Y
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
Cat
Felis silvestris
Mouse
Mus musculus
O88572
1613
180236
Y1522
Y
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
Rat
Rattus norvegicus
Q9QYP1
1905
211861
L1815
K
I
V
E
G
I
H
L
L
A
G
H
D
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508455
1480
165692
R1390
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
T
Chicken
Gallus gallus
XP_417286
1567
175502
Y1477
Y
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
Frog
Xenopus laevis
NP_001079233
1613
180585
Y1522
Y
S
Y
R
P
Y
N
Y
R
H
F
A
P
P
T
Zebra Danio
Brachydanio rerio
NP_001128156
1620
180715
Y1526
Y
S
Y
R
P
Y
S
Y
R
H
F
A
P
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P98163
1984
219502
Y1821
A
G
L
G
Y
M
Y
Y
Q
Y
R
Q
R
G
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202408
1322
148003
Y1232
I
C
E
D
S
E
P
Y
S
M
G
G
A
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
28.8
99.1
N.A.
97.8
28.3
N.A.
86.7
86.4
85.1
81.3
N.A.
20.1
N.A.
N.A.
42.2
Protein Similarity:
100
100
43.4
99.8
N.A.
99.3
45
N.A.
89.8
92
92.8
90.4
N.A.
36.1
N.A.
N.A.
56.5
P-Site Identity:
100
100
6.6
100
N.A.
100
0
N.A.
13.3
100
93.3
100
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
6.6
100
N.A.
100
0
N.A.
13.3
100
100
100
N.A.
20
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
9
9
9
59
9
17
9
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
0
0
0
0
9
0
17
0
0
% D
% Glu:
0
0
9
9
0
9
0
0
0
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
59
0
0
0
0
% F
% Gly:
0
9
9
9
9
0
0
0
0
0
17
9
0
9
0
% G
% His:
0
9
0
0
0
0
9
0
9
59
0
9
0
0
9
% H
% Ile:
9
9
0
0
0
9
0
0
0
9
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
9
0
9
9
0
0
0
9
9
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
9
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
9
59
0
9
0
0
0
0
9
67
67
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% Q
% Arg:
0
0
9
59
9
0
0
9
59
0
9
0
9
0
0
% R
% Ser:
9
59
0
0
9
9
50
0
9
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
67
% T
% Val:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
59
9
59
0
17
59
17
75
0
9
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _